In glycolysis under aerobic conditions, what is the net ATP and NADH gained per glucose?

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Multiple Choice

In glycolysis under aerobic conditions, what is the net ATP and NADH gained per glucose?

Energy accounting in glycolysis shows that, per glucose, two ATP are invested early to activate the molecule, and four ATP are produced later, giving a net gain of two ATP. Along with this, two NAD+ molecules are reduced to NADH during the oxidation of glyceraldehyde-3-phosphate, yielding two NADH per glucose. Under aerobic conditions, those NADH molecules can be shuttled into mitochondria and used to generate more ATP via oxidative phosphorylation, but the glycolysis step itself contributes a net of two ATP and two NADH. So the correct pairing is a net gain of two ATP and two NADH per glucose.

Energy accounting in glycolysis shows that, per glucose, two ATP are invested early to activate the molecule, and four ATP are produced later, giving a net gain of two ATP. Along with this, two NAD+ molecules are reduced to NADH during the oxidation of glyceraldehyde-3-phosphate, yielding two NADH per glucose. Under aerobic conditions, those NADH molecules can be shuttled into mitochondria and used to generate more ATP via oxidative phosphorylation, but the glycolysis step itself contributes a net of two ATP and two NADH. So the correct pairing is a net gain of two ATP and two NADH per glucose.

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