Identify three allosteric regulators of PFK-1 and indicate whether they activate or inhibit the enzyme.

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Multiple Choice

Identify three allosteric regulators of PFK-1 and indicate whether they activate or inhibit the enzyme.

Glycolysis is controlled at the PFK-1 step by regulators that reflect the cell’s energy needs. When energy is low, AMP and ADP rise and bind to PFK-1, promoting its active form and speeding up glycolysis to generate more ATP. When energy is plentiful, ATP binds to an allosteric site and inhibits PFK-1, dialing back glycolysis to avoid wasteful glucose breakdown. So the three regulators in this context are AMP (activates), ADP (activates), and ATP (inhibits). In many tissues, fructose-2,6-bisphosphate is also a strong activator, but the trio described here demonstrates the standard balance between activating signals of low energy and the inhibitory signal of high energy.

Glycolysis is controlled at the PFK-1 step by regulators that reflect the cell’s energy needs. When energy is low, AMP and ADP rise and bind to PFK-1, promoting its active form and speeding up glycolysis to generate more ATP. When energy is plentiful, ATP binds to an allosteric site and inhibits PFK-1, dialing back glycolysis to avoid wasteful glucose breakdown. So the three regulators in this context are AMP (activates), ADP (activates), and ATP (inhibits). In many tissues, fructose-2,6-bisphosphate is also a strong activator, but the trio described here demonstrates the standard balance between activating signals of low energy and the inhibitory signal of high energy.

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